Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp144 | Cell biology: osteoblasts and bone formation | ECTS2014

Pro-osteogenic properties of nacre extract on two cell lines, primary human osteoblasts and MC3T3-E1 cell line

Brion Alice , Zhang Ganggang , Piet Marie-Helene , Moby Vanessa , Bianchi Arnaud , Dossot Manuel , Mainard Didier , Galois Laurent , Gillet Pierre , Rousseau Marthe

Nacre, or mother of pearl, is a promising natural biocompatible biomaterial consisting of aragonite (97%) and of organics (3%) and capable to increase the cell osteogenic activity. It has been established that osteoarthritic osteoblasts present a mineralization defect and, to date, only a few molecules (vitamin D3 and bone morphogenetic protein2) could improve the mineralization potential of this cell type. In this context, we evaluated the impact of nacreous molecules on the ...